Pain, Opioids and Pro-Inflammatory Immune Responses
Status:
Terminated
Trial end date:
2012-05-01
Target enrollment:
Participant gender:
Summary
Providing pain management to the patient who abuses prescription opioids presents a clinical
challenge, not only due to concerns about "drug-seeking", but because they have increased
sensitivity to pain, a phenomenon identified as opioid-induced hyperalgesia (OIH). In an
effort to improve pain treatment, the aims of the proposed work are to evaluate the analgesic
and hyperalgesic effects of opioids to acute pain in this vulnerable population, and to
examine the role of opioid-induced proinflammatory changes in these responses.