Pain Reduction After Cholecystectomy

• Status: Completed
• Trial end date: 2010-01-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine the effect of combined intracutaneous infiltration and intraperitoneal instillation of 80 mL 0,125% levobupivacaine prior to the start of laparoscopic cholecystectomy on abdominal pain up to 24 hours after surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Meander Medical Center
• Treatments: Bupivacaine; Levobupivacaine

Criteria

Inclusion Criteria:

• between 18 and 80

• ASA I or II

• with symptomatic gallstone disease which requires elective laparoscopic cholecystectomy

Exclusion Criteria:

• acute cholecystitis, cholangitis, severe acute pancreatitis, advanced liver cirrhosis or suspected gallbladder cancer,

• a medical history of epilepsy, cardiac arrhythmias or chronic pain of any kind, - allergy to amid type drugs

• pregnancy

• patients suffering from hypotension or hypovolemia

• infectious liver disease

• conditions obstructing adequate pain scoring

• patients using drugs that deduce function of the CYP3A4 or CYP1A2 system

• patients having an American Society of Anaesthesiologists (ASA) classification of three or higher.