The search for new safe and effective methods of pain relief after surgery on large joints is
still an urgent problem. The most optimal approach in the treatment of postoperative pain is
the use of multimodal analgesia with a different mechanism of action that act on various
mechanisms of pain and can include opioids, nonsteroidal anti-inflammatory drugs (NSAIDs),
acetaminophen, anticonvulsants, NMDA antagonists, alpha-2-agonists, and sodium and calcium
channel blocking agents, as well as local anesthetics. NSAIDs are the most popular and safe
means for pain relief. Therefore, a lot of efforts are aimed at increasing the effectiveness
of NSAIDs use. The aim of this study was to evaluate the effectiveness of simultaneously
administering two or three NSAIDs, compared to using only one NSAID, for pain relief after
surgery on large joints such as hip or knee arthroplasty.
Phase:
N/A
Details
Lead Sponsor:
Federal State Budgetary Organization, Federal Center for Traumatology, Orthopedics and Arthroplasty