Pain and Medical Abortion Among Teenaged Women Compared to Adult Women

• Status: Completed
• Trial end date: 2018-08-31
• Target enrollment: 0
• Participant gender: Female

Summary

In this two-parted study the need and sufficiency of analgesics and experienced pain is compared between teen-aged and adult women undergoing medical termination of pregnancy (MToP)in early pregnancy (under 9weeks of gestation). During MToP at pregnancy weeks 9-20 on-demand administration of opiates and patient-controlled analgesia (PCA) are compared in randomized clinical trial.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Helsinki University Central Hospital
• Collaborators: Helsinki University; University of Helsinki

Criteria

Inclusion Criteria:

• Patients who choose medical method of abortion

• First pregnancy

• Age between 15 and 19 years or 25 and 35 years

• Patients volunteer in the study

Exclusion criteria for inquiry part are

• Patient's serious illness

• Known allergy to one of the trial medications

• Abortion is done based on foetal abnormality or threat of patient's own health

Exclusion criteria for intervention part are

• Abortion is done based on foetal abnormality or threat of patient's own health

• Minor patient does not want to inform guardian

• More than one foetus

• Patient's serious illness (ASA-class 3 or 4)

• Massive obesity (BMI >35 kg/m2)

• Known allergy to one of the trial medications

• History of opioid abuse

• Problems of understanding (Inability of use PCA or to understand VAS)

• Active bleeding before intake of first Misoprostol dose

• One of next medications: ketokonatsol, erythromycin, claritromycin, verapamil or diltiazem or medication against HIV (CYP3A4-transmitted interaction with oxycodon)