Paliperidone and Lithium in the Treatment of Suicidality - Treatment Indication and Epigenetic Regulation
Status:
Completed
Trial end date:
2014-02-01
Target enrollment:
Participant gender:
Summary
The study aims to use a combined clinical and translational approach to identify an efficient
pharmacotherapy for the acute management of suicidality and the epigenetic regulation
associated with the treatment.The primary objective is a clinical trial to compare the
efficacy of paliperidone versus lithium and placebo as adjunctive therapy to the standard of
care antidepressants in the acute management of suicidality in depressed subjects.
Specific Aims 1 and 2 are described in detail below. Analysis for Specific Aim 2 is still
underway.
Phase:
Phase 4
Details
Lead Sponsor:
University of Alabama at Birmingham
Collaborators:
American Foundation for Suicide Prevention Ortho-McNeil Janssen Scientific Affairs, LLC