Pancreatic Perfusion Using Secretin and MRI

• Status: Unknown status
• Trial end date: 2016-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to assess pancreatic perfusion in patients with chronic pancreatitis at rest and after secretin stimulation and compare this to published data on pancreatic perfusion in normal subjects.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Nottingham
• Treatments: Secretin

Criteria

Inclusion Criteria:

• Adults with chronic pancreatitis (as defined by the Cambridge criteria)

Exclusion Criteria:

1. Allergy to secretin

2. Claustraphobia

3. Refusal to consent for the study

4. MRI contraindications e.g. pacemaker, artificial heart valve

5. Previous abdominal surgery except appendectomy or hernia repair

6. History of chronic abdominal pain from causes other than pancreatitis eg. inflammatory bowel or coeliac disease

7. Pregnant women (safety concerns from injection of secretin)

8. Patients younger than 18 years of age