Paracetamol Compared With Ketorolac for Post-operative Analgetic

• Status: Completed
• Trial end date: 2022-08-02
• Target enrollment: 0
• Participant gender: All

Summary

Post-operative analgetic modalities vary between center to center, especially in Indonesia. Considerations include potency/effectivity of the analgetics to achieve adequate pain control as soon as possible, reducing the total opioid dose intake and overall reducing potential opioid adverse effects. NSAID have been known to have more adverse effects than acetaminophen (paracetamol) but offers a higher potency for analgetic effects. Here we compare whether paracetamol is adequate as a post-operative analgetics and confers fewer overall adverse effects when compared with ketorolac (NSAID)

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Indonesia University
• Collaborator: Dr Cipto Mangunkusumo General Hospital
• Treatments: Acetaminophen; Ketorolac

Criteria

Inclusion Criteria:

• Postoperative patients admitted to Neurosurgery HCU or PICU

• Parents/guardian signed informed consent forms

Exclusion Criteria:

• History of allergy to paracetamol and ketorolac

• Administration of opioid 24 hours before surgery

• Liver dysfunction

• Renal failure