Paracetamol Metabolism Research in Postoperative Hepatic Surgery
Status:
Unknown status
Trial end date:
2020-01-01
Target enrollment:
Participant gender:
Summary
The main objective of this study was to evaluate the 5-day kinetics of plasma paracetamol
levels in postoperative major hepatic surgery (resection greater than or equal to three
hepatic segments) compared with less extensive liver resection and hepatic re-intervention.
The clearance of indocyanine green is a marker of hepatic perfusion but also of the proper
hepatocyte functioning, if hemodynamic conditions are stable.
Some patients may be operated on up to four or five times in the liver. Moreover, these
patients probably present an increased risk of postoperative hepatocellular insufficiency due
to a quantitative and qualitative decrease in their hepatic parenchyma. It is therefore
interesting to evaluate the use of paracetamol in this situation.