Paracetamol Vs Caffeine Vs Codeine in the Management of Post Traumatic Pain in Emergencies

• Status: Recruiting
• Trial end date: 2022-02-28
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to:

Compare the effect of paracetamol alone against Paracetamol+Codeine association against the association of paracetamol + Cafeine in the treatment of post-traumatic acute pain of the limbs.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Monastir
• Treatments: Acetaminophen; Caffeine; Codeine

Criteria

Inclusion Criteria:

• age 18 years or older

• acute (<24 hours) post traumatic pain of the extremity and requiring analgesic treatment upon discharge for pain with intensity >3 on a visual numeric scale

Exclusion criteria:

• open fracture head, abdominal, thoracic or polytrauma.

• Need for hospitalization, regular use of paracetamol and NSAIDs during the two weeks before admission to ED history of allergy or hypersensitivity to either paracetamol or Codeine or cafeine

• acute /history of GI hemorrhage and renal insufficiency,

• an inability to assess pain intensity according to the VNS.

• Pregnancy

• heart failure

• known hepatic cirrhosis

• known severe renal impairment (Creatinine clearance <30 ml/min)

• swallowing disorders

• Refusal, incapacity or difficulties to consent or to communicate