Parameters Associated With the Emergence of Resistance to Ciprofloxacin in Human Commensal Flora
Status:
Terminated
Trial end date:
2005-07-01
Target enrollment:
Participant gender:
Summary
Bacterial resistance to antibiotics has been a growing therapeutic problem since the late
1980s. Resistant strains of pathogenic bacteria can arise through initial selection of
resistant strains in the commensal flora. The emergence of fluoroquinolone resistance in the
commensal flora will be assessed in 48 healthy volunteers receiving variable doses of
ciprofloxacin during 14 days. Emergence of resistance will be correlated to pharmacokinetic
characteristics of ciprofloxacin.