Paraoxonase and LDL Oxidation in Carotid Artery Disease
Status:
Completed
Trial end date:
2003-09-01
Target enrollment:
Participant gender:
Summary
Atherosclerosis of the carotid arteries is a common cause of stroke. The prevalence and
progression of carotid atherosclerosis are believed to be influenced by genetically inherited
variations in lipoprotein metabolism. This study investigates the specific role of
paraoxonase, an enzyme thought to detoxify atherogenic oxidized low-density lipoprotein. This
study compares veterans who have significant carotid atherosclerosis on ultrasound
examination with controls without carotid atherosclerosis. Both paraoxonase activity and
genotype will be determined and compared between groups. The results may eventually make it
possible to screen for a paraoxonase allele that confers high risk of atherosclerosis, and to
diminish the risk by early treatment.
Details
Lead Sponsor:
US Department of Veterans Affairs VA Office of Research and Development