Paravertebral Morphine Versus Dexmedetomidine on Acute and Chronic Postmastectomy Pain

• Status: Unknown status
• Trial end date: 2018-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

Evaluate the effect of addition of morphine, dexmedetomidine to bupivacaine in PVB could improve the analgesic effect and thus reduce postoperative morphine consumption and development of chronic neuropathic pain, compared to PVB with bupivacaine , in patients undergoing major breast cancer surgery, i.e., modified radical mastectomy (MRM) and breast conservation surgery with axillary lymph node dissection.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Bupivacaine; Dexmedetomidine; Morphine

Criteria

Inclusion Criteria:

• physical status classes I to III ( weight 50 - 85 kg), will be scheduled for unilateral modified radical mastectomy (MRM) with axillary evacuation will be consecutively enrolled.

Exclusion Criteria:

• patient refusal,

• patients with a known allergy to investigated drugs,

• bleeding disorders,

• anatomical abnormalities,

• infection in the paravertebral region,

• pregnancy, breast feeding,

• a history of drug or alcohol abuse, and patients with chronic pain or regularly receiving analgesics.

• patients subjected for bilateral mastectomy or any unilateral breast surgery other than MRM with axillary evacuation.