Parenteral Antibiotics Compared to Combination of Oral and Parenteral Antibiotics in Colorectal Surgery Prophylaxis
Status:
Completed
Trial end date:
2018-11-10
Target enrollment:
Participant gender:
Summary
Routine antibiotics for the intravenous and oral prophylaxis of colorectal surgery will be
used.
Experimental group: Patients undergoing elective colorectal surgery that involves, colonic
resection.
The antibiotic prophylaxis in this group will be composed of:
An oral antibiotic pattern of ciprofloxacin (750mg / 12h, 2 doses) and metronidazole (250mg /
8h, 3 doses) the day before surgery.
+
Control group: Patients undergoing elective colorectal surgery that involves, colonic
resection.
The antibiotic prophylaxis in this group will be composed of:
An intravenous antibiotic pattern of cefuroxime 1g and metronidazole 1,5gr during anesthetic
induction.
In both groups a second intravenous dose of cefuroxime (750mg) will be administered if the
intraoperative time elongates more than three hours or there is an intraoperative bleeding
over 1000cc.
There won´t be a placebo treatment. Subject compliance will be evaluated according to the
usual practice in surgical care field
Phase:
Phase 4
Details
Lead Sponsor:
Hospital Universitari Vall d'Hebron Research Institute