Paricalcitol, Fluorouracil, and Radiation Therapy in Treating Patients With Rectal Cancer That Can Be Removed in Surgery
Status:
Terminated
Trial end date:
2014-04-01
Target enrollment:
Participant gender:
Summary
This randomized pilot clinical trial studies the side effects of giving paricalcitol together
with fluorouracil and radiation therapy in treating patients with rectal cancer that can be
removed in surgery. Paricalcitol may help rectal cancer cells become more like normal cells,
and to grow and spread more slowly. Drugs used in chemotherapy, such as fluorouracil, work in
different ways to stop the growth of tumor cells, either by killing the cells or by stopping
them from dividing. Radiation therapy uses high energy x rays to kill tumor cells. It not yet
known if chemotherapy and radiation therapy are more effective with or without paricalcitol
in treating rectal cancer
Phase:
Phase 1
Details
Lead Sponsor:
Comprehensive Cancer Center of Wake Forest University Wake Forest University Health Sciences