Paroxysmal Atrial Fibrillation: Role of Inflammation, Oxidative Stress Injury and Effect of Statins

• Status: Completed
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the effect of statin therapy for prevention of atrial fibrillation (AF) in pacemaker and non-pacemaker patients with paroxysmal atrial fibrillation in the absence of significant coronary artery disease.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Calgary
• Collaborators: Canadian Institutes of Health Research (CIHR); Merck Sharp & Dohme Corp.
• Treatments: Simvastatin

Criteria

Inclusion Criteria:

• Patients with paroxysmal AF (> 3 epis each > 15 min in length) over 6 months

• Patients on stable antiarrhythmic drug therapy and life expectancy > 1 year

Exclusion Criteria:

• Patients with PAF due to reversible cause

• Chronic inflammatory conditions

• Other medical conditions requiring statin therapy

• Patients on amiodarone or verapamil

• Elevated CK or ALT

• Life expectancy <1 year

• TAVN ablation

• Geographic isolation

• Inability to give informed consent