Patient-controlled Intravenous Analgesia With Remifentanil Infusion for Labour

• Status: Terminated
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

Epidural analgesia for pain relief in labor may not be suitable for all patients, and intravenous patient controlled analgesia (IV PCA) with opioids offers the best alternative. The purpose of this study is to assess the effectiveness of two methods remifentanil administration in the form of either an infusion or PCA demand bolus (intravenous injection of a single dose over a short period of time). Currently, our hospital gives remifentanil by demand bolus, however it may be equally effective, with less side effects, to give the drug as an infusion.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital
• Treatments: Remifentanil

Criteria

Inclusion Criteria:

• Written informed consent

• Term pregnancy in labour with singleton fetus in cephalic presentation

• Patients requesting systemic analgesia

• Patients with contraindication for regional anesthesia without fetal compromise (coagulopathy, thrombocytopenia, refusal, etc.)

Exclusion Criteria:

• Refusal to sign written informed consent

• Inability to communicate in English

• Opioid dependence or addiction

• Patients on Methadone

• Allergy or hypersensitivity to remifentanil

• Fetal heart rate abnormalities

• Fetal congenital anomalies