Patients-Controlled Epidural Analgesia After Gastric Bypass for Morbid Obesity Using Morphine-Levobupivacaine Regimens

• Status: Completed
• Trial end date: 2012-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Adequate postoperative analgesia can facilitate recovery following gastric bypass surgery for morbid obesity. The efficacy and safety of intravenous patient - controlled analgesia has been studied, but up to date no data are available concerning the use of thoracic epidural patient-controlled analgesia regarding the use of levobupivacaine combined with morphine in morbidly obese patients. The investigators' aim in this prospective, randomized, double-blinded study was to compare the analgesic effectiveness, the dose requirements and side effects of thoracic epidural patient controlled analgesia 0.1% and 0.2% levobupivacaine combined with a continuous epidural administration of morphine, with or without a loading dose, after open gastric bypass for morbid obesity.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Patras
• Treatments: Bupivacaine; Levobupivacaine; Morphine

Criteria

Inclusion Criteria:

• Body mass index (BMI) > 50

• Age < 50

• Patients written consent to participate in the study

Exclusion Criteria:

• Cardiovascular disease (valvular and ischemic heart disease)

• Patients refusal to participate in the study

• Contraindication to epidural catheter placement (e.g anticoagulation, anti- platelets medication)

• Active psychiatric disease requiring treatment

• Redo surgery