PeRiodontal Treatment to Eliminate Minority InEquality and Rural Disparities in Stroke
Status:
Unknown status
Trial end date:
2020-06-01
Target enrollment:
Participant gender:
Summary
The PREMIERS study is a proposal for conducting an adequately powered two center phase III
randomized controlled trial to test whether intensive periodontal treatment reduces the risk
of recurrent vascular events among ischemic stroke and TIA survivors. The study uses the
resources in both states including established dental centers, Joint Commission Certified
Stroke Centers, the Schools of Public Health, and the Institute for Partnerships to Eliminate
Health Disparities. The proposal addresses specific issues with regards to recruitment of
African-American and rural stroke/TIA patients advocating the use of culturally appropriate
strategies to educate the study subjects regarding stroke, periodontal disease and the
periodontal stroke link.
The study proposes to utilize economic evaluation of the periodontal intervention from the
budgetary perspective. The focus will be on the financial sustainability of providing
aggressive periodontal therapy (with certain, although relatively low expenditures) in
exchange for a reduction of uncertain recurrent vascular events that may require high cost
emergency department utilization and/or inpatient care. The sustainability of the proposed
intervention after the completion of the project is integrally linked to the health economic
assessment to show the health care cost savings. By integration with a rural primary care
center, with an African American majority and households with average incomes below the state
average, the study ensures that the proposed intervention to reduce stroke disparity is
applicable to this target population.