Penicillin and Metronidazole in Treatment of Peritonsillar Abscess

• Status: Completed
• Trial end date: 2011-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Treatment of peritonsillar abscess varies. To study whether broad spectrum antibiotics are required in addition to abscess drainage, a prospective, double blind, placebo-controlled, randomized study on 200 adult patients with peritonsillar abscess is performed. 100 patients are given penicillin and metronidazole and 100 patients get penicillin and placebo. Recovery and recurrence are analyzed.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Helsinki University Central Hospital
• Treatments: Metronidazole; Penicillins

Criteria

Inclusion Criteria:

• referring doctor suspects peritonsillar abscess

• patient is voluntary

• patient has daily access to his/her e-mail

• patient speaks and understands Finnish of Swedish

• female patients have adequate birth-control method

• patient has peritonsillar abscess

Exclusion Criteria:

• allergy to penicillin

• allergy to metronidazole

• use of metronidazole in preceding one month

• pregnancy

• breast-feeding

• renal insufficiency

• liver insufficiency

• alcoholism (drunk at least once a week)

• participant in another clinical trial at the moment

• treatment of peritonsillar abscess requires in-patient care

• tonsillectomy during the next 30 days

• army recruit