Pentoxifylline Dose Optimization in Neonatal Sepsis
Status:
Recruiting
Trial end date:
2021-01-01
Target enrollment:
Participant gender:
Summary
Sepsis is a very important cause of death and morbidity in preterm infants. There are strong
indications that preterm neonates with sepsis could benefit, next to antibiotics, from
treatment with pentoxifylline (PTX). Knowledge about optimal dosing is however limited. This
study is a dose optimization study using a step-up and step-down model. In order to find the
optimal dose, the infusion of pentoxifylline in different dosages will be studied, next to
antibiotics with 3 patients per dosage. After the dose optimization study an additional
cohort of 10 patients will be treated with the found dosage as a validation of the dose.