Pentoxifylline and Systemic Inflammation in Hemodialysis Patients

• Status: Completed
• Trial end date: 2008-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study was to compare the effect of PTX vs placebo on serum concentrations of TNF-α, IL-6, and CRP in patients on hemodialysis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Coordinación de Investigación en Salud, Mexico
• Treatments: Pentoxifylline

Criteria

Inclusion Criteria:

• Age ≥18 years,

• ≥2 months on HD,

• arteriovenous fistula as vascular access, and

• endorsement of informed consent.

Exclusion Criteria:

• inflammatory cause of ESRD,

• liver disease, cancer, AIDS,

• any infectious disease 2 months before the study,

• failed kidney graft,

• hypersensitivity to PTX or other methylxanthines,

• hemorrhage/clotting disorders,

• risk for worsening pre-existing cardiac arrhythmias or arterial hypotension,

• treatment with antibiotics, non-steroidal anti-inflammatory drugs, steroids, immunosuppressives, statins or PTX 3 months previous to the study