In children 7-12 years of age with functional abdominal pain (n=42) determine:
Aim 1 - To examine and characterize the threshold of the exposure (PK) vs. response (PD)
relationship of PMO (menthol)
Aim 2 - PD of PMO as assessed by:
1. Microbiome composition (16S RNA sequencing)
2. Transit rate/contractile activity (using the SmartPill®) Aim 3 - Evaluate the potential
association between PD response and clinical symptoms (abdominal pain and stooling
pattern via validated diary), psychosocial distress (anxiety, depression, somatization),
and characterize potential side effects (questionnaire)