Peppermint Oil for the Treatment of Irritable Bowel Syndrome: Optimizing Therapeutic Strategies Using Targeted Delivery
Status:
Completed
Trial end date:
2018-10-01
Target enrollment:
Participant gender:
Summary
Peppermint oil has shown to be effective in the treatment of Irritable Bowel Syndrome (IBS)
symptoms in several meta-analyses. However, the level of evidence is moderate and peppermint
oil remains relatively under-used in IBS. Therefore, the investigators will conduct a
multicenter randomized, placebo controlled trial to investigate the effects of an eight-week
peppermint oil treatment in IBS patients according to current European Medicines Agency (EMA)
/ US Food and Drug Administration (FDA) guidelines. To improve efficacy and to reduce side
effects, the investigators aim to study the use of a new peppermint oil formulation, a
colon-targeted-delivery capsule that will release the oil in the (ileo-) colonic region
specifically.
Phase:
Phase 3
Details
Lead Sponsor:
Maastricht University Medical Center
Collaborator:
ZonMw: The Netherlands Organisation for Health Research and Development