Perineural Dexmedetomidine for Ulnar Nerve Block.

• Status: Unknown status
• Trial end date: 2018-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this trial is to investigate if dexmedetomidine prolongs the duration of an ulnar nerve block. By using healthy volunteers the investigators can perform bilateral ulnar nerve blocks and thereby control for a systemic effect to clarify if the effect is actually peripheral or systemic. The investigators hypothesis is that dexmedetomidine as an adjunct to a local anaesthetic prolongs the duration of a peripheral nerve block by a peripheral mechanism.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Zealand University Hospital
• Treatments: Dexmedetomidine; Ropivacaine

Criteria

Inclusion Criteria:

• Participants must understand the protocol fully and sign the written in-formed consent.

• ASA 1-2

• BMI > 18 to < 30

• For fertile women: safe contraceptives for the last month and a nega-tive urin HCG.

Exclusion Criteria:

• Participants unable to cooperate in the trial.

• Participants unable to speak or read Danish

• Allergy to study medication.

• Alcohol consumption >21 units for men and >14 for women per week

• Daily intake of prescription painkillers within the last 4 weeks.

• Over the counter painkillers during the last 48 hours.

• Neuromuscular defects or wounds on the arms or hands preventing test performance.

• Diabetes Mellitus

• 2. degree heart block

• Sick sinus node.

• For fertile women a positive urine HCG