The primary aim of this pilot study is to determine whether the test methods described
feasibly achieve the goal defined for a future clinical study. The purpose is a quantitative
assessment of the bactericidal effect of two adjunctive treatments compared to that of
conventional periodontal maintenance debridement. Patients who meet eligibility criteria and
are enrolled in the study will receive the standard of care, whole mouth periodontal
maintenance treatment using ultrasonic scalers to debride deposits within the gingival
sulcus. Subsequently, each of three of the quadrants will be randomly assigned to a test
group (keeping the fourth quadrant as the control), thus, a "split-mouth" study design.
Microbial samples will be collected using sterile paper points inserted into each tooth site
involved in the study at baseline (S1) before test treatment and one week after test
treatment (S2). Samples will be analyzed with real time qPCR to identify and quantify
specific periodontal pathogens. Data analysis will compare the post-treatment results to
baseline, the control treatment arm to the test treatment arm, and the test treatments among
each other.