Periodontal Debridement Associated With Systemic Antibiotics and Single/Repeated PDT to Treat Aggressive Periodontitis

• Status: Completed
• Trial end date: 2016-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this project is to compare the efficacy and the local effect of the association of single or repeated application of photodynamic therapy (PDT) with antibiotic agents using Amoxicillin + Metronidazole or Clarithromycin in the treatment of patients with Generalized Aggressive Periodontitis (GAgP).

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Universidade Estadual Paulista Júlio de Mesquita Filho
• Treatments: Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Metronidazole

Criteria

Inclusion Criteria:

• diagnosis of GAgP (Armitage, 1999; American Academy of Periodontology, 2015);

• presence of ≥20 teeth, excluding third molars and teeth indicated for extraction;

• presence of ≥6 sites presenting PD ≥5 mm with bleeding on probing and ≥2 sites with PD ≥7 mm (including incisors and first molars, in addition to two other non-contiguous teeth between them);

• presence of three non-adjacent periodontal pockets with probing depth ≥5 mm and bleeding on probing not located in furcation area;

• good general health (ASA I/II);

• 18-35 years old;

• agree to participate in the study and sign a written consent (Resolution # 196 of October 1996 and the Brazilian Professional Code of Dental Ethics - 179/93).

Exclusion Criteria:

• pregnant or nursing;

• suffer from any systemic disease (e.g. cardiovascular, diabetes, blood dyscrasias, immunodeficiency, etc - ASA III/IV/V);

• antimicrobials or anti-inflammatory drugs in the previous 6 months;

• periodontal treatment within the last 12 months;

• smoke ≥10 cigarettes/day;

• reported allergy to amoxicillin, metronidazole or clarithromycin;

• required antibiotic prophylaxis;

• current use of any medication that could interfere with periodontal response were excluded from the study.