Perioperative Administration of Gabapentin for Reducing Inhalational Anesthetic Consumption
Status:
Enrolling by invitation
Trial end date:
2023-07-30
Target enrollment:
Participant gender:
Summary
Gabapentin, a structural analog of gamma aminobutyric acid (GABA), was introduced within the
us as an anticonvulsant, used clinically to treat epilepsy. The drug causes amino acids
release within the medulla spinalis dorsal horn and thus decreasing response to neural inputs
and stabilizing the nervous activity. The mechanism of action of gabapentin on neuropathic
pain is assumed to bind to the alpha 2 delta subunit of the voltage-dependent calcium channel
within the central systema nervosum , reducing calcium influx into the nerve terminals and
decreases the release of neurotransmitters like glutamate . Gabapentin, therefore, can be
used for controlling chronic pain, as in diabetic neuropathy and other neuropathic disorders
. Some studies examined the effectiveness of gabapentin for acute postoperative pain
management for gynecological surgery, lumbar spinal surgery, arthroplasty, and thoracic
surgery . A recent study concluded that gabapentin has a role in preoperative anxiolysis,
attenuation of hemodynamic response to intubation, prevention of postoperative nausea and
vomiting (PONV) and finally postoperative delirium . Up to date, the effect of preoperative
gabapentin on inhaled anesthetic depth is unknown