Perioperative Administration of Pregabalin for Pain After Septoplasty
Status:
Unknown status
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
Pregabalin is used for the treatment of neuropathic pain and has shown analgesic efficacy in
postoperative pain. The aim of this randomized, double-blinded, placebo-controlled trial was
to investigate the efficacy and safety of pregabalin for reducing postoperative pain in
patients after septoplasty. Persons who scheduled for elective septoplasty under general
anesthesia were randomly assigned to groups that received either pregabalin (150 mg twice) or
placebo, one hour before surgery and 12 hours after the initial dose. Assessments of pain
(verbal numerical rating scale) and side effects were performed at one, six, 12, and 24 hours
postoperatively.