Perioperative Administration of Pregabalin for Pain After Septoplasty

• Status: Unknown status
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Pregabalin is used for the treatment of neuropathic pain and has shown analgesic efficacy in postoperative pain. The aim of this randomized, double-blinded, placebo-controlled trial was to investigate the efficacy and safety of pregabalin for reducing postoperative pain in patients after septoplasty. Persons who scheduled for elective septoplasty under general anesthesia were randomly assigned to groups that received either pregabalin (150 mg twice) or placebo, one hour before surgery and 12 hours after the initial dose. Assessments of pain (verbal numerical rating scale) and side effects were performed at one, six, 12, and 24 hours postoperatively.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Samsung Medical Center
• Treatments: Pregabalin; Vitamins

Criteria

Inclusion Criteria:

• Age 20 ≥ and ≤ 65 years

• Patients with nasal packing after septoplasty

Exclusion Criteria:

• previous septal surgery history

• postoperative complications including septal hematoma, bleeding ets.

• Current therapy with pregabalin, gabapentin, or any opioid

• Renal insufficiency

• History of seizure disorder