Perioperative Dexamethasone on Postoperative Outcome in IBD

• Status: Completed
• Trial end date: 2020-01-13
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this RCT is to determine the efficacy of a single preoperative dose of Dexamethasone for accelerating the recovery and reducing the incidence of postoperative complications in adult patients undergoing intestinal resection for inflammatory bowel disease.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Jinling Hospital, China
• Treatments: Anesthetics; BB 1101; Dexamethasone; Dexamethasone acetate

Criteria

Inclusion Criteria:

1. Patients undergoing elective open and laparoscopic small and large bowel operations for IBD, including Crohn's Disease(CD) and Ulcerative Colitis (UC).

2. ASA I-III

Exclusion Criteria:

1. Diabetes or hyperglycemia

2. Active gastric ulceration confirmed endoscopically

3. Presence of ongoing infection (such as IAS) or infective chronic diseases

4. Currently receiving systemic therapy with glucocorticoids with prednisolone >=20mg for over 6 weeks within 30 days prior to surgery.

5. Emergent surgery

6. Acute angle glaucoma

7. Pregnancy

8. Under 18 years of age

9. Known adverse reaction to dexamethasone

10. Extensive adhesiolysis

11. Carcinogenesis of intestinal tract