Perioperative Fluid Therapy With Balanced Crystalloids

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Introduction: The strategy of perioperative fluid therapy has an important impact not only on the circulating volume and perfusion of organs and tissues but also on the patient's internal environment. The study aimed at comparing the effects of perioperatively administered balanced crystalloid infusion solutions containing different amounts of metabolizable anions on homeostasis.

Methods: In the prospective randomized study, patients were assigned to Plasmalyte (PL) and Ringerfundin (RF) Groups after their postoperative transfer to an intensive care unit (ICU). The infusion solutions were parenterally administered at 1000 mL/6 hours. Arterialized capillary blood was sampled at the time of transfer to the ICU (Time 0), and again at 2 hours and 6 hours from Time 0. The collected blood was tested for blood gas parameters using the Astrup method.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Olomouc
• Treatments: Pharmaceutical Solutions; Plasma-lyte 148

Criteria

Inclusion Criteria:

• age 18+

• elective surgery procedures

Exclusion Criteria:

• critically ill, being classified as ASA III or less

• surgery longer than 6 hrs

• hypersensitivity to PL or RF

• requiring more rapid fluid replacement (than 1000 ml/6 hrs) due to postoperative hypovolemia