Perioperative Intravenous Lidocaine Infusion for Patients Undergoing Laparoscopic and Open Pancreatectomies

• Status: Completed
• Trial end date: 2018-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate if a lidocaine infusion will provide benefit to pancreatectomy patients in regards to analgesia and return of bowel function.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mayo Clinic
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

• All adult patients undergoing elective open or laparoscopic total pancreatectomies and pancreatoduodenectomies (i.e., Whipple procedure), and participating in the Enhanced Recovery Protocol (ERP) at Mayo Clinic in Florida.

• Age 18 - 80 years old

• American Society of Anesthesiologist (ASA) class I - III

• BMI < 40

• Ability to understand and read English

Exclusion Criteria:

• Not able or willing to sign consent

• Intolerance or allergy to opioids, NSAIDS, acetaminophen, or amide-type local anesthetics (i.e., lidocaine).

• History of epilepsy or currently receiving treatment for seizures

• Severe hepatic insufficiency (Child-Pugh Score C)

• Renal insufficiency (creatinine clearance less than 30 mL/minute)

• Advance heart failure (NY Heart failure stage 3 or greater; Ejection function <30%)

• Cardiac arrhythmias: 2nd and 3rd degree heart block, sick sinus syndrome, symptomatic bradyarrhythmias, Wolff-Parkinson-White (WPW) syndrome, or Stokes-Adams syndrome; Left bundle branch block or bifascicular block; Not to exclude patients the following conditions unless clinical circumstance dictate: Atrial fibrillation or atrial fluTter; Presence of Implantable Cardioverter Defibrillator (ICD), or pacemakers

• Patients on anti-arrhythmic therapy (i.e., digoxin, amiodarone, flecainide, lidocaine, sotalol, etc.). Not to exclude patients on beta blockers (i.e., metoprolol, atenolol, etc.) unless clinical circumstance dictate

• Patients with active psychiatric disorders or cognitive dysfunction

• Pregnancy or lactating

• Enucleation, central, and distal pancreatectomy

• Opioid tolerance (defined as consumption of greater than 30 mg of oxycodone per day)