Perioperative Lidocaine and Ketamine in Abdominal Surgery

• Status: Recruiting
• Trial end date: 2022-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators propose to test the hypothesis that perioperative infusions of lidocaine and/or ketamine reduce opioid consumption and pain scores in adults recovering from elective inpatient abdominal surgery.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: The Cleveland Clinic
• Treatments: Ketamine; Lidocaine

Criteria

Inclusion Criteria:

• Adults 18 to 80 years old

• Elective inpatient open or laparoscopic abdominal surgery

• General anesthesia lasting 2 hours or longer.

Exclusion Criteria:

• 1. Planned postoperative mechanical ventilation

• 2. Planned regional anesthesia/analgesia

• 3. Perioperative gabapentin, magnesium, or nitrous oxide use

• 4. Pregnancy or breastfeeding

• 5. Morbid obesity (BMI ≥ 35 kg/m2)

• 6. American Society of Anesthesiologists (ASA) physical status IV-V

• 7. Allergy to study medications

• 8. Contraindication to lidocaine (severe cardiac arrhythmia)

• 9. Contraindication to ketamine (psychiatric disorder, substance abuse, uncontrolled hypertension, pulmonary hypertension, increased intracranial or intraocular pressure, use of monoamine oxidase inhibitors)

• 10. Chronic preoperative opioid use (≥ 90 morphine mg equivalents per day for > 3 months)

• 11. Significant preoperative hepatic dysfunction (alanine aminotransferase or aspartate aminotransferase levels > 5 times normal) or planned liver transplantation

• 12. Preoperative cardiac failure (left ventricular ejection fraction ≤ 40%)

• 13. Unable to communicate or comprehend study instructions