Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients

• Status: Recruiting
• Trial end date: 2021-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Acute pain management following major surgical procedures in pediatric patients continues to be a challenge, especially after extensive posterior spine fusions.

Spine surgery is particularly traumatic, initiating pain in both peripheral and central pathways. While the standard management of post-surgical pain involves a multimodal approach, opioids provide the predominant benefit. However, opioid use is associated with many adverse effects, including nausea, constipation, and pruritus. Perioperative methadone may decrease total opioid consumption and adverse effects as well as improve satisfaction with pain management after scoliosis repair.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical College of Wisconsin
• Treatments: Methadone; Morphine

Criteria

Inclusion Criteria:

• Age 10-18 years

• Idiopathic scoliosis

• Fusion levels planned for 10 or greater

• English speaking

• American Society of Anesthesiology (ASA) class 1 - 3

Exclusion Criteria:

• Current narcotic use / History of substance abuse

• Morphine, hydromorphone or methadone allergies

• Pregnancy

• Seizure Disorders

• Bleeding disorders

• Neuromuscular scoliosis

• Non-English speaking