Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone
Status:
Unknown status
Trial end date:
2012-08-01
Target enrollment:
Participant gender:
Summary
Background: In perioperative period inhibition of N-Methyl-D-Aspartate receptor prevents
opioid-induced hyperalgesia and reduce postoperative opioid requirement after abdominal
surgery. Methadone is both a ยต-opioid receptor agonist like Morphine and a
N-Methyl-D-Aspartate antagonist. Study Aim. To evaluate the efficacy of intraoperative
Ketamine and postoperative Methadone analgesia in preventing opioid-induced hyperalgesia
after abdominal surgery.
Phase:
N/A
Details
Lead Sponsor:
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano