Perioperative Use of Tranexamic (TXA) in Bone Tumor Surgery Reduce Blood Loss and Transfusion Requirements.

• Status: Recruiting
• Trial end date: 2024-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this trial is to investigate whether previously reported benefit of Tranexamic acid in pediatric orthopedic surgeries could be recapitulated in bone tumor surgeries or not through a double blinded randomized controlled trial done in children cancer hospital 57357.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Children's Cancer Hospital Egypt 57357
• Treatments: Tranexamic Acid

Criteria

Inclusion Criteria:

1. Malignant bone tumor of the femur and finished neoadjuvant chemotherapy

2. Candidate for resection and reconstruction by prosthesis. 3- Age 4-18 years.

Exclusion Criteria:

1. Anatomic location other than femur de

2. Reconstruction other than prosthesis

3. Allergy to TXA

4. Previous history of DVT

5. Previous history of renal dysfunction

6. Congenital or acquired coagulopathy.

7. Congenital or acquired cardiomyopathy.

8. Previous history of convulsions.