Perioperative Use of a Selective COX2 Inhibitor in Patients Undergoing Elective Colorectal Surgery: the Effect on Post-operative Bowel Motility and Post-operative Pain

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Perioperative Celecoxib to promote bowel movement and to reduce post-operative pain after elective colonic resection.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sheba Medical Center
• Treatments: Celecoxib

Criteria

Inclusion Criteria:

• Patients between the age of 18 and 80

• Patients planned for elective colorectal surgery with primary anastomosis

• ASA score of 1-3

• Patients that are able to sign an informed consent and comply with the protocol

Exclusion Criteria:

• Patients with inflammatory bowel disease

• Patients that require emergency surgery

• Patients with renal failure, measured by Creatinine level > 1.5 mg/dL (>106.1 micro mol/l)

• Patients with significant liver failure (known cirrhosis, Bilirubin level>2 mg/dL or 34.2 µmol/L)

• Patients with known allergy to any medication from the non-steroidal anti-inflammatory drug group.

• Patients treated chronically with any type of COX inhibitor.

• Patients treated with NSAIDS including Aspirin 7 days prior to the date of surgery.

• Patients with active peptic disease

• Patient expected to take muscle relaxants, tricyclic antidepressants, tranquilizers, sedatives, hypnotics or neuroleptics in the postoperative period

• Patient with dysphagia or that have a difficulty swallowing capsules or tablets, or is unable to tolerate oral medication

• Pregnant / lactating women.

• Patients participating in any other interventional clinical trial