Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty

• Status: Recruiting
• Trial end date: 2026-02-28
• Target enrollment: 0
• Participant gender: All

Summary

Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total knee arthroplasty surgery.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Health Network, Toronto
• Collaborators: Canadian Institutes of Health Research (CIHR); The Arthritis Society, Canada
• Treatments: Ascorbic Acid

Criteria

Inclusion Criteria:

• Patients >18 years old

• Undergoing a unilateral or bilateral primary total knee arthroplasty for advanced osteoarthritis of the knee

Exclusion Criteria:

• TKA for infection (septic joint), fracture, ankylosing spondylitis, lupus, or psoriatic arthritis

• History of kidney stones, acute or chronic renal failure, hemochromatosis, or glucose-6-phosphate deficiency

• Unlikely to comply with follow-up (e.g., no fixed address, plans to move out of town)

• Language difficulties that would impede valid completion of questionnaires

• Planned staged bilateral TKA

• Treating surgeon deems patient inappropriate for inclusion in trial

• Any allergy or sensitivity to milk

• Pregnant or planning to become pregnant during the study