Peripapillary Blood Flow After Use of Anti-glaucoma Medications: An OCT Angiography Study

• Status: Completed
• Trial end date: 2020-05-30
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluates the possible acute changes in peripapillary blood flow after instillation of antiglaucoma medications in patients with primary open angle glaucoma (POAG), normal tension glaucoma (NTG), or ocular hypertension (OHTN) using Optical Coherence Tomography (OCT) angiography.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Wills Eye
• Collaborator: Optovue
• Treatments: Brimonidine Tartrate; Maleic acid; Timolol

Criteria

Inclusion Criteria:

• Diagnosis of ocular hypertension, primary open angle glaucoma, or normal tension glaucoma in the study eye(s)

• Age 18-90

• Best corrected visual acuity of 20/60 or better

Exclusion Criteria:

• Current use of either brimonidine or timolol

• Other disease, ophthalmic or systemic, that is likely to significantly affect the OCT test in the study eye(s) including:

• More than moderate grade cataract that significantly reducing OCTA scan signal level

• Macular degeneration other than mild drusen or pigmentary changes

• Diabetic retinopathy other than mild background non proliferative retinopathy

• Prior or current macular edema

• Prior laser treatment to the retina

• Prior retinal detachment

• Prior central serous retinopathy

• Prior retinal vein or artery occlusion

• Prior inflammatory retinopathy or choroidopathy

• Keratoconus or other corneal ectasia

• Corneal scarring in central 4 mm

• Prior penetrating keratoplasty

• Ischemic optic neuropathy

• Dementia beyond early/mild memory loss

• History of cerebrovascular accident

• History of severe carotid stenosis

• History of previous ocular surgery other than non-complicated cataract extraction