Peripheral Nerve Blocks for Above-the-knee Amputations

• Status: Recruiting
• Trial end date: 2022-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Surgery performed with nerve blocks and sedation may be safer and provide better pain control compared to general anesthesia and opioid therapy in high-risk patient populations such as elderly and troubled with peripheral vascular disease, diabetes, hypertension, coronary artery disease, and chronic obstructive pulmonary disease (COPD).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Florida
• Collaborator: US Department of Veterans Affairs
• Treatments: Dexmedetomidine; Hypnotics and Sedatives; Propofol

Criteria

Inclusion Criteria:

• Patients undergoing above-the-knee amputation or knee disarticulation

• Ability to understand and provide informed consent

Exclusion Criteria:

• Patient refusal or inability to provide informed consent

• True allergy, not sensitivity, to any of the following substances:

• - Local anesthetics

• - Propofol or other sedative agents

• - General anesthetic agents

• Pregnancy

• Severe hepatic impairment

• Evidence of infection at or near the proposed needle insertion site

• Any sensorimotor deficit, whether acute or chronic, as determined by the PI

• Chronic use of opioid medication

• BMI ≥ 35