Personalizing Preprocedural Sedation for Regional Anesthesia

• Status: Not yet recruiting
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a prospective, randomized study in patients who receive a nerve block prior to surgery. The aim is to investigate whether individual differences in psychosocial and pain profiles may play a role in how patients experience sedation for regional anesthesia. The study will utilize a mixed-methods approach, including a randomized controlled intervention and semi-structured interviews, in order to systematically investigate the relationship between an individual patient's level of catastrophizing and efficacy of procedural sedation, while exploring patient satisfaction with the preoperative nerve block experience.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Brigham and Women's Hospital
• Treatments: Fentanyl; Midazolam

Criteria

Inclusion Criteria:

• Age≥18

• English speaking

• Willingness to undergo psychophysical testing

• Willingness to have nerve block performed

• Surgical or procedural patient

• Single shot nerve block

Exclusion Criteria:

• Cognitive dysfunction that precludes communication

• Declines or is not eligible clinically to receive sedation with midazolam and/or fentanyl at discretion of the non-study clinical team (Examples: frailty, cognitive dysfunction)

• Allergy or hypersensitivity to midazolam or fentanyl

• Declines nerve block

• Does not complete survey needed for randomization

• Current pregnancy and/or breastfeeding