Pertussis Vaccination Among HIV-infected and HIV-uninfected Pregnant Women
Status:
Not yet recruiting
Trial end date:
2025-06-01
Target enrollment:
Participant gender:
Summary
Pertussis (also known as whooping cough) is a highly contagious, vaccine-preventable
respiratory tract disease, caused by the bacteria Bordetella pertussis. It can affect people
of all ages, however young unimmunised or partially immunised infants are the most vulnerable
group with the highest rates of complications and death. Recent surveillance data and an
increase in the number of pertussis outbreaks being reported nationally, indicate an increase
in the incidence of pertussis disease in South Africa.To date there is no data on the effect
of vaccinating HIV-infected pregnant women with pertussis-containing vaccines, although there
is no reason to think that vaccinating these women would be harmful for them or their foetus.
The knowledge gaps on the immunogenicity, safety and VE of pertussis vaccination of
HIV-infected pregnant women should be addressed. Adacel which is a registered and licensed
vaccine manufactured by Sanofi Pasteur, will be tested in this study.