Ph I/II Nab-Paclitaxel & Carboplatin w/Concurrent Radiation Therapy for Unresectable Stg III NSCLC
Status:
Terminated
Trial end date:
2014-04-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as carboplatin, work in different ways to stop
the growth of tumor cells, either by killing the cells or by stopping them from dividing.
Radiation therapy uses high-energy x-rays to kill tumor cells. Nab-paclitaxel (paclitaxel
albumin-stabilized nanoparticle formulation) may make tumor cells more sensitive to radiation
therapy. Giving nab-paclitaxel together with radiation therapy and carboplatin may kill more
tumor cells.
PURPOSE: This phase I/II trial is studying the side effects and best dose of giving
nab-paclitaxel together with carboplatin and radiation therapy and to see how well it works
in treating patients with stage III non-small-cell lung cancer that cannot be removed by
surgery.