Ph1 Marinol Interaction Study - Part 2 - 1

• Status: Completed
• Trial end date: 2007-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will examine the effects of oral dronabinol tetrahydrocannabinol (THC) on withdrawal symptoms in marijuana dependent volunteers, and evaluate the safety, pharmacokinetics (PK), and cardiovascular effects of the combination of oral dronabinol and smoked marijuana to determine if there are potential significant drug interactions before conducting outpatient studies.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: National Institute on Drug Abuse (NIDA)
• Treatments: Dronabinol

Criteria

Inclusion Criteria:

• Must be between 18 and 45 years of age

• Must be in good general health and who meet DSM-IV diagnostic criteria for marijuana dependence

• Must be seeking treatment at time of study entry

• Must be able to understand and provide written informed consent

• Must provide 1 marijuana positive urine specimen (> 50 ng/mL) within the 28-day screening period

• If female and of child bearing potential, agrees to use birth control.

Exclusion

Criteria:

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