Pharmacodynamics and Pharmacokinetics of Dexmedetomidine in Pediatric

• Status: Unknown status
• Trial end date: 2019-07-01
• Target enrollment: 0
• Participant gender: All

Summary

1. Acute Hemodynamic and respiratory Changes After Rapid Intravenous different doses of Dexmedetomidine in Pediatric.

2. Pharmacokinetics after a single Rapid Intravenous dose of Dexmedetomidine in Pediatric.

3. Pharmacokinetics after a single dose of Dexmedetomidine administered as a nasal spray in Pediatric.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chinese Medical Association
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• selective operation of inguinal hernia repair、orthopedics operation or general surgery operation in children

• aged 3-9 years

• ASA I - II

• enter the operating room by himself without parents

• normal liver and kidney function

• no history of anesthesia medication allergy.

Exclusion Criteria:

• allergic to dexmedetomidine, similar active ingredients or excipients

• G-6-PD deficiency

• a history of arrhythmia, bronchial and cardiovascular diseases, abnormal liver function and so on

• a history of use of alpha 2 receptor agonists or antagonists.