Pharmacogenetic Factors and Side Effects of Metoclopramide and Diphenhydramine

• Status: Terminated
• Trial end date: 2015-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Pharmacokinetic of Metoclopramide (MCP) in correlation to polymorphisms of CYP2D6 and Dopamine-D2-Receptor. Pharmacokinetic of Diphenhydramine (DPH) in correlation to polymorphisms of CYP2D6

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Matthias Schwab
• Treatments: Diphenhydramine; Metoclopramide; Promethazine

Criteria

Inclusion Criteria:

• BMI 20 - 27kg/m2

• Caucasians

• Healthy volunteers

Exclusion Criteria:

• Pregnancy/lactation period

• Drug allergy

• Acute and chronic diseases

• Taking medication

• Abuse of drugs, alcohol etc.

• Smoker