Pharmacokinetic Analysis of High Dose Methotrexate in Pediatric Lymphoblastic Malignancies

• Status: Completed
• Trial end date: 2010-02-01
• Target enrollment: 0
• Participant gender: All

Summary

• The pharmacokinetics of MTX were assessed with regards to the relevance of several different patient specific factors in 291 pediatric patients, who were administered with high dose of MTX. Population pharmacokinetics of MTX analysis was performed by using nonlinear mixed effects modeling.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Children's Hospital of Zhejiang University School of Medicine
• Treatments: Methotrexate

Criteria

Inclusion Criteria:

• Acute lymphoblastic leukemia and non-hodgkin's lymphoma younger than 18 years old

Exclusion Criteria:

• Non lymphoblastic malignancies or older than 18 years