Pharmacokinetic Evaluation of Nalmefene Administered Intranasally to Healthy Volunteers

• Status: Completed
• Trial end date: 2017-07-03
• Target enrollment: 0
• Participant gender: All

Summary

This study will be to compare the pharmacokinetics of nalmefene administration intranasal with and without an absorption enhancer compared to an intramuscular injection.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: National Institute on Drug Abuse (NIDA)
• Treatments: Nalmefene; Naltrexone

Criteria

Inclusion Criteria:

• Males and females 18 to 55 years of age

• Provide written informed consent

• Body Mass index (BMI) ranging from 18 to 32 kg/m2

• Adequate venous access

• No clinically significant concurrent medical conditions

• Males subjects must agree to use an acceptable method of birth of contraception with female partners as well as not to donate sperm throughout the study and for 90 days after the last study drug administration

• Female subjects of child bearing potential must agree to use an acceptable method of birth control from the start of screening until 30 days after completing the study. Oral contraceptives are prohibited

• Agree not to ingest alcohol, drinks containing xanthine >500 mg / day (e.g., Coca Cola, tea, coffee, etc.), or grapefruit/grapefruit juice or participate in strenuous exercise 72 hours prior to admission through the last blood draw of the study

Exclusion Criteria:

• Please contact the site for more information