Pharmacokinetic-Pharmacodynamic Relationship of Metformin in Healthy Volunteers

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: Male

Summary

Two doses of metformin with 12 hour interval

• low dose group (375/250 mg)

• high dose group (1000/1000mg)

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Metformin

Criteria

Inclusion Criteria:

• Age 20 to 45

• Body weight 50 to 100 kg

• fasting serum glucose 70 to 125 mg/dL

• who provide informed consent voluntarily

Exclusion Criteria:

• any significant renal, gastrointestinal, hepatic, and metabolic condition

• any co/prior medication within 14 days of study drug administration