Pharmacokinetic, Pharmacodynamic and Pharmacogenetic of Morphine After Surgery

• Status: Completed
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The main objective of this study is to improve our knowledge on the pharmacodynamic, pharmacokinetic, and pharmacogenetic relationships of morphine administered to relief severe postoperative pain. The analysis will encompass the efficacy (acute during titration and subacute during the first 24 hours) and adverse effects of morphine. Our purpose is also to better characterize the age- and sex-related differences which probably markedly differ between the two periods (acute vs sub acute).

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: Morphine

Criteria

Inclusion criteria :

• scheduled major orthopedic surgery

• spine, hip or knee surgery

• Body weight between 50 and 100 kg

• Caucasians

• ASA status 1 to 3

• no cognitive dysfunction

Exclusion criteria :

• allergy or contraindication to morphine

• renal impairment (Cr Cl < 30 ml/min)

• severe hepatic impairment

• surgery performed under regional anaesthesia

• preoperative treatment including strong or weak opioids

• pregnancy, patients under 18 years, addiction