Pharmacokinetic, Safety and Tolerability Study of SC Administered Bisphosphonate With rHuPH20 vs Bisphosphonate Alone
Status:
Completed
Trial end date:
2009-09-21
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine the maximum tolerated concentration (MTC) of
bisphosphonate with a fixed dose of rHuPH20 administered SC, the MTC of bisphosphonate
without rHuPH20 administered SC, the optimal dose of rHuPH20 to deliver bisphosphonate SC at
MTC, and to compare the PK of SC administered bisphosphonate at MTC with optimal dose rHuPH20
to bisphosphonate alone.